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In this episode John and Professor Shah open with why insulin alone has structural limitations in type 1 diabetes, work through how GLP-1 therapies act on the body, and then walk the trial evidence from the early exenatide and liraglutide studies to the more recent semaglutide and tirzepatide data

Today, GLP-1 RAs are commonly prescribed to treat obesity and type 2 diabetes and to lower the risk of heart attack and stroke

Tirzepatide, a dual GLP-1 and GIP receptor agonist, produces rapid weight loss by regulating appetite and blood sugarbut some patients experience dizziness during treatment initiation

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