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Among the studies included in this systematic review, ten directly and one indirectly evaluated the effects of pharmacological interventions modulating this signaling pathway

A 2020 preclinical study evaluating gabapentin in an experimental colitis model demonstrated: Reduced visceral hypersensitivity Decreased inflammatory signaling Reduced mast cell density and activation markers in colonic tissue Downregulation of pro-inflammatory pathways (including NF-B signaling) Mast cells and enteric nerves communicate bidirectionally in the gut

It also activates AMPK signaling pathways in neural tissues, enhancing autophagy and improving neuronal energy metabolism

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