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Furthermore, visual inspection of the funnel plot revealed the asymmetric distribution (online Supplementary Fig

After discontinuation, close monitoring is essential: weight should be checked every 4-8 weeks initially, and for diabetes patients, self-monitoring of blood glucose or continuous glucose monitoring should continue as indicated, with A1C assessment within approximately 3 months of stopping to detect metabolic deterioration early and implement alternative management strategies

Compounded versions can also include added ingredients like vitamins or other medications

In a clinical trial where neither the participants nor the researchers knew who received the actual drug or a fake pill (placebo), 314492 adults who were overweight or obese (with an average body mass index of 36.2) were randomly assigned to take either lorcaserin (10 mg) or placebo twice a day for 52 weeks