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Firstly, the synthesis of GSH-depleted multicomponent nanomedicines is so time-consuming that it still faces a huge technological gap from laboratory preparation to industrial production ( 5 Conclusion and outlook Cancer cells show overexpressed GSH that may maintain redox homeostasis to protect cells from oxidative damage, as well as reduce the chemotherapeutic agent-induced toxification

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Because the expression of SLC7A11 proteins in H2122 cells is higher than in other SWI/SNF proficient cell lines, high expression levels of SLC7A11 in H2122 cells may be associated with genetic abnormalities involved in multiple NRF2 activations

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