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The FDA has reported 392 adverse events with compounded semaglutide and 215 with compounded tirzepatide, including multiple hospitalisations from dosing errors

potentially fatal disturbances of cardiac conduction (widening of QRS), arrhythmias & seizures due to Na channel block (cardiac & CNS) Pharmacokinetics: PO, metabolized in the liver (P450 - 2D6)

Statistical analysis Descriptive statistics and group comparisons : Baseline characteristics were summarized using descriptive statistics

Another strategy involves the use of PARP inhibitor BGP-15, which might protect against CC, to enhance mitochondrial homeostasis 260,261