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The balance between oxidative demand and redox buffering capacityas well as between catabolic drive and anabolic substrate supportmay therefore become an important determinant of tissue resilience and the durability of pharmacologically induced weight loss

Defects in complex I are among the most common causes of mitochondrial diseases, contributing to disorders such as Leigh syndrome, mitochondrial encephalomyopathy and Parkinsons disease by disrupting ATP production and elevating oxidative stress 21,71,72,73