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Cis-aconityl linkers are formed by conjugating cis-aconitic acid with amines to create acid-sensitive amide bonds, releasing payloads via acid-catalyzed hydrolysis

The cDNA for SLC7A11 coding region was amplified from ZR-75-1 breast cancer cell line using standard RT-PCR and ligated into EcoR I- Sal I linearized retroviral pBabe-hygro vector, generating the pBabe-hygro-SLC7A11

The company is not required to post public financial disclosures and could not be reached to verify those figures

One of the primary causes of skin aging is a decrease in the synthesis of collagen and elastin, proteins that provide firmness to the skin