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These drugs are effective for weight loss because they increase insulin levels, which turns the body into a "fat-burning machine," in addition to suppressing appetite

doi:10.1002/hep.21006

Basal insulin (such as insulin glargine or insulin degludec) can be added to existing oral regimens, including those containing Rybelsus or Januvia, though careful dose titration and glucose monitoring are essential to minimise hypoglycaemia risk