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To test whether this result is transferrable from 2D fibroblast culture to 3D human skin models, we extracted RNA from EFT-412 skin tissues following two-week MB treatment at 0.1, 0.5 and 2.5 M concentrations

For peripheral nerve analysis, a 5-mm-long piece of tail 15 mm distal from the tail base was collected from each sacrificed animal, fixed in 4% formaldehyde in phosphate buffer (pH 7.4), decalcinated, and impregnated with 1% osmium tetroxide for a few days

Once a product has been discarded, Abi Cole Aesthetics will be unable to issue a refund or replacement

Understanding these mechanisms helps contextualise why traditional weight management approaches may prove challenging during this life stage