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In adipose models, reduced NNMT activity has been linked with smaller adipocyte size and diminished fat depots, suggesting a potential role for this inhibitor in fat mass modulation under research conditions

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IGF-1 mediates many of growth hormones anabolic effects, including muscle protein synthesis, bone growth, cartilage formation, and cellular proliferation

doi: 10.1111/j.1365-2265.2009.03667.x 49 DelgrangeERaverotGBexMBurmanPDecoudierBDevuystFet al