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One study 15 found that NAC was beneficial in reducing the mortality rate in patients with COVID-19 and inflammatory parameters and led to a reduction in the development of severe respiratory failure

However, the altered tissue microenvironment characteristic of chronic metabolic and inflammatory diseases significantly impairs neutrophil function, resulting in aberrant responses and tissue damage

96,97 Moreover, the ME1 protein is hypophosphorylated at S336 and hyperacetylated at K337 by PGAM family member 5 and acetyl-CoA acetyltransferase, respectively, resulting in ME1 translocation from mitochondria to the cytosol, dimerization and activation, thus strongly promoting NADPH generation and tumorigenesis

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