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Known Side Effects Reported side effects are generally mild and infrequent: Injection site reactions: temporary redness, mild swelling, or tenderness Nausea: occasionally reported, usually mild and transient Dizziness: rare, typically with first doses Fatigue: some users report temporary tiredness Headache: infrequent, usually resolves quickly These effects typically diminish with continued use and rarely require treatment discontinuation

Andreasen, C

Yes many people find that four to five smaller, more frequent meals spread throughout the day are far better tolerated than three larger meals, as retatrutide slows gastric emptying and can cause uncomfortable fullness if portions are too large

In most cases, treatment progression is gradual, with visible skin tone improvements developing over multiple sessions rather than after a single injection