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Metformin-induced lactic acidosis with emphasis on the anion gap

In participants with type 2 diabetes receiving the 8mg weekly dose, baseline A1C averaged 8.1%

doi: 10.1016/j.cmet.2017.10.009

The inhibition of Na + reabsorption thus, prevents the normally associated K + efflux to the lumen, hence the potassium-sparing effects of these drugs