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In a systematic review, researchers analyzed the gut microbiomes of patients with depression and found substantial differences in microbiome composition compared to healthy individuals, particularly in the abundance of certain bacterial genera, such as Prevotellaceae and Blautia [493, 494]

When the body becomes more responsive to insulin, cravings often decrease, energy becomes steadier, and weight loss feels more achievable

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Berberine is a known inhibitor of several cytochrome P450 enzymes (particularly CYP3A4) and P-glycoprotein transporters in laboratory studies, though the clinical significance at typical supplemental doses remains uncertain