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unopposed oestrogen carries a significant risk of endometrial hyperplasia and cancer, both of which are conditions for which obesity is also an independent risk factor

Because tirzepatides effect on birth-control absorption is strongest after your first injection and each time you up your dosage, the FDA recommends either switching to non-oral birth control (such as an IUD) or adding in a barrier method (like condoms) for at least four weeks after starting Mounjaro or increasing your dose

Medicare Part D beneficiaries with a BMI of 35 or higher, a BMI of 30 or higher with heart failure, uncontrolled hypertension, or chronic kidney disease, or a BMI of 27 or higher with prediabetes, a prior heart attack or stroke, or symptomatic peripheral artery disease