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using liraglutide 3 mg/day compared with placebo, despite the lack of changes in total testosterone levels, confirmed the increase in SHBG levels, with a consequent reduction in free Androgen Index (FAI), and also a restoration in menstrual cyclicity [62]

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Ozempic or Wegovy should not be used in individuals with: Pregnancy or breastfeeding Severe gastrointestinal disease History of pancreatitis (requires careful assessment) The UK product information notes that animal studies have shown an increased incidence of thyroid C-cell tumours with semaglutide, though the human relevance of this finding is unknown