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Findings showed that there the Melasma Area and Severity Index of the intervention group was significantly lower than that of the placebo group at week eight and 12 of the study

Additionally, a time-of-day dependent vasoreactivity exists (Durgan et al., 2017), further supporting the notion of circadian regulation of the cardiovascular system

Despite the promising therapeutic potential of polyphenols like curcumin and resveratrol, their clinical application is often hindered by poor bioavailability, rapid metabolism, and low chemical stability