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Brown DA, Perry JB, Allen ME, Sabbah HN, Stauffer BL, Shaikh SR, et al

We know so little about it formally, but people are suffering

Unfortunately, this compensatory surge is futile because the downstream clearance pathwaysspecifically the enzymes mitochondrial superoxide dismutase (SOD2) and glutathione peroxidase 4 (GPX4)are severely dysfunctional

High-Fat/High-Calorie Diets Promote Postprandial Oxidative Stress (POS), Mitochondrial OxS, and Insulin Resistance In healthy young adults, the consumption of a lipid (saturated fat)-rich meal results in robust postprandial oxidative stress (POS) compared to an isocaloric carbohydrate-rich meal (dextrose) [89]