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The administration of GLP-1R agonists to individuals with NAFLD reduced liver fat content, normalized plasma aminotransferase levels and promoted histological improvements in terms of hepatocellular inflammation, preventing fibrosis progression [7478]

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Sublingual administration, which bypasses the gastrointestinal tract, appears to be equally effective as IM injections while being less invasive and more cost-efficientparticularly in patients with atrophic gastritis, post-gastrectomy status, or conditions that impair intrinsic factor-mediated absorption, where long-term intervention is often required