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Months 3 to 6: Skin thickness and tissue recovery effects, when they appear, settle in around this window

In the SUSTAIN 7 trial, injectable semaglutide therapy was more effective than dulaglutide therapy in reducing glycated hemoglobin (HbA1c) levels and body weight (BW) in patients with T2DM [14]

Table of Contents Understanding Metformins Historical Role Emerging Evidence and New Therapeutic Classes Guideline Perspectives on Metformin in 2026 Clinical Scenarios: When to Use or DePrioritize Metformin Practical Considerations for Prescribers Conclusion Frequently Asked Questions Understanding Metformins Historical Role Since its adoption decades ago, metformin has served as the default first-line treatment for type 2 diabetes

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