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ver el artculo sobre Riboflavina), una flavina defectuosa que contiene enzima monooxigenasa 3 (FMO3) da como resultado una oxidacin deteriorada de la trimetilamina en el hgado

SAXENDA was evaluated for safety in 5 double-blind, placebo controlled trials that included 3,384 overweight or obese adult patients treated with SAXENDA for a treatment period up to 56 weeks (3 trials), 52 weeks (1 trial), and 32 weeks (1 trial) and one trial of 56 weeks in 125 pediatric patients with obesity aged 12 years and older [see Clinical Studies (14.1, 14.2)]

PMID: 33667417

The global prevalence of DM continues to rise, affecting 537 million adults in 2021 and projected to rise to 783 million by 2045, representing a substantial public health burden (42)