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Approval asymmetry

Standing beside drug execs in the Oval Office earlier this month, Trump announced deals with Eli Lilly and Novo Nordisk that will cut the price of their GLP-1 weight loss medicines, Zepbound and Wegovy, in return for a three-year exemption from his 100% pharmaceutical tariffs

However, with high or chronic levels of oxidative stress this effect gets much larger and the loss of cysteines is quite large

However, reducing equivalents are needed as well in order to activate ERO1 (Kim, Sideris, Sevier, & Kaiser, 2012) and to reduce disulfide isomerases so that they can catalyze reduction of improper disulfide bonds (Schwaller, Wilkinson, & Gilbert, 2003)