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Transl Psychiatry (2016) 6:e972.10.1038/tp.2016.223 121 Cipolla-NetoJAmaralFGAfecheSCTanDXReiterRJ

Some patients may lose more weight, while others may lose less, and weight changes usually happen gradually over several months

Pathogenesis An increased number of melanocytes within the basal layer of the epidermis leads to an increased production of melanin, resulting in hyperpigmented macules