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The drug manufacturer faces multidistrict litigation (MDL) filed in federal district court for the Eastern District of Pennsylvania

In a Phase II study reported in 2024 involving 168 patients with NASH, moderate to advanced fibrosis (F2F3), and NAS 4, a significantly greater proportion of patients in the denifanstat group achieved the primary endpoint compared with placebo, with statistically meaningful improvements in fibrosis as well

Discovered in 2015, MOTS-c functions as a signaling molecule that helps the body respond to metabolic stress by improving glucose uptake, enhancing insulin sensitivity, and promoting fat metabolism

Some clinics offer IV therapy, but they administer a large dose in a short time, which can cause side effects like feeling cold, achy and sick