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Human observational studies associate folate-rich diets with lower aneuploidy and better assisted reproductive technology outcomes, while omega-3 fatty acids aid chromatin remodeling via histone deacetylase regulation

Open questions also include an unresolved debate in the peer-reviewed literature about the implications of BPC-157s pro-angiogenic activity for cancer-relevant signaling pathways, raised in a 2025 literature review and disputed by the original research group

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Deregulation of any of the cooperating factors can lead to prolonged inflammation with chronic exposure to cytotoxic mediators (Coussens and Werb, 2002)