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1000 IU/d may be beneficial to children and may have the effect of controlling epilepsy ( 3 ) in newborns, is associated with an increased risk of childhood epilepsy (epilepsy first diagnosed at 14 years of age) ( 5.3 Dietary therapy for children with epilepsy A ketogenic diet was first recommended for the treatment of epilepsy by Wilder in 1921, and ketogenic diets were widely recommended for children with epilepsy between 1921 and 1930 ( 5.4 Metabolic effects of ASMs on children Long-term sodium VPA use had significant negative effects on bone mineral density and vitamin D levels in children with epilepsy ( Figure 2G ) treatment, and daily oral sodium chloride in children with epilepsy treated with monotherapy can safely and effectively reduce the incidence of hyponatremia ( Figure 2H ) had no significant long-term effect on body weight in children with epilepsy ( 6 Epilepsy metabolomics 6.1 Metabolomic analysis for epilepsy diagnosis An increasing number of researchers are exploring new biomarkers for the diagnosis of epilepsy via metabolomic analysis