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(3) This theorized pathway involves the activation of phospholipase C (PLC), which some researchers believe may lead to the increased release of inositol triphosphate (IP3) and diacylglycerol (DAG)

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Studies in mice, however, have shown that Nestin expression in brain reaches a nadir around 18 days of life and that most cells that express Nestin postnatally are relatively inactive in adulthood unless an injury, such as hypoxia to the brain, occurs (3335)