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Specifically, SIRT3 deacetylates and inhibits aldehyde dehydrogenase 2, which prevents the conversion of acetaldehyde to acetate, potentially leading to acetaldehyde toxicity 183

This approval represents a meaningful shift in obesity treatment and insurance coverage strategies, especially for employers evaluating weight-management benefits

Relying on the medication alone to lose weight is not going to yield optimal results

Susan Spratt, an endocrinologist and the senior medical director of the Population Health Management Office at Duke Health in North Carolina, who was not involved in the studies, applauded the research, saying the findings show that obesity is not a vanity issue. This is about treating a major health problem that reduces significant morbidity and mortality, she said