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Given that the transcription factor ATF3 induces P21 CIP expression while high c-Jun activity represses P53-mediated P21 CIP induction, 38, 39 the precise c-Jun/ATF2 and ERK1/2 activations regulate the transient increase in p21 CIP protein amounts required to stabilize CyclinD/CDK4/6 complexes from 36 to 40 h in WT mice

DOI: 10.1146/annurev.arplant.47.1.127 28

Stress, dehydration, too much screen time, not enough sleep these everyday headaches are uncomfortable, but they're usually short-lived and respond well to rest and over-the-counter pain relievers

But losing too much weight to the point where youre underweight isnt good either, and can cause your period to stop altogether