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The migration and invasion of RA-FLS cells may be mediated by the production of MMP-2 and MMP-9, and exogenous MMP-9 pretreatment can reverse the inhibitory effect of artesunate on the invasion of RA-FLS (119)

However, the market remained relatively small until semaglutide, initially approved for type 2 diabetes under the brand name Ozempic, gained widespread attention for its significant weight loss effects

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