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Perhaps its most famous role, GLP-1 crosses the blood-brain barrier to act directly on appetite centres in the brain, enhancing feelings of fullness and reducing hunger signals

It has also been shown to result in a lower adenosine triphosphate (ATP) cost of muscle force production [13], which suggests that shorter-term supplementation of L-citrulline malate might improve skeletal muscle metabolism

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PMID: 31775249