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Notably, dieckol demonstrated strong binding affinity to AChE (binding energy: 9.6 kcal/mol) and secretase (BACE1), suggesting its potential as a lead compound

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Thus, no evidence currently indicates that patients with HFrEF benefit from the administration of GLP-1RAs, but rather, the increased arrhythmias and death are concerning

In patients with renal dysfunction, refractory hypotension, severe metabolic abnormalities, active seizure, or persistent coma, extracorporeal removal by haemodialysis or haemofiltration may be considered, although there are no controlled trials that demonstrate an improvement in outcome with these measures [8890]