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Science 356 , eaal3321 (2017)

And at the end of the day, the goal is simple

Calcium channel blockers are suggested as a second-line agent, followed by a diuretic as a third-line antihypertensive agent

Notably, the simultaneous use of both pharmacological classes provided a significantly greater benefit in outcomes such as mortality, hospitalizations, heart failure, and CKD ( Building on the findings of the aforementioned trials, several meta-analyses have been conducted since 2019 to evaluate the safety and efficacy of combining GLP-1 RAs and SGLT-2 inhibitors