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This property allows SCFAs to exert multidimensional regulatory effects: they can directly or indirectly influence circulatory function and peripheral tissue metabolism, while also modulating the functional states of various central cell types, such as microglia, thereby playing a pivotal role in processes closely related to neuroinflammation and neurological health

Sam Raney is the Associate Director for Science and Chief Scientific Advisor in the FDAs Office of Research and Standards and Office of Generic Drugs, where he oversees the research portfolio of FDAs generic drug research program

Nevertheless, although coronary calcium scores may have a predictive value regarding future cardiac events in asymptomatic subjects, it may not be a reliable marker of plaque burden in symptomatic patients (96, 97)

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