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At the cellular level, GHK-Cu has been shown to increase collagen synthesis in fibroblast cultures by stimulating TGF- signaling and upregulating collagen type I and III gene expression

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The scientific papers reviewed for this article involve enzyme systems, cultured cells, rats or mice

J Nutr 132:283288 Jacques PF, Bostom AG, Selhub J, Rich S, Ellison RC, Eckfeldt JH et al (2003) Effects of polymorphisms of methionine synthase and methionine synthase reductase on total plasma homocysteine in the NHLBI Family Heart Study