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Endothelial dysfunction and microclot formation have also been proposed as central components of Long COVID and the microvascular nature of the disease [336, 350]

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GLP-1R agonists effect(s) on vascular smooth muscle cells are equally important to those on endothelial cells with several favorable responses being reported, including enhanced differentiation, attenuated response to reactive oxygen species, reduced vascular remodeling through improved mitochondrial activity and dynamics, and the prevention of aberrant migration [65]

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