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Nevertheless, the "Danger Theory," put forward by Polly Matzinger in 1994, contends that the fundamental impetus for immune activation is not solely the discrimination between self and nonself, but rather the detection of danger signals, encompassing bacterial toxins, viruses, rapidly proliferating tumor cells, and nonprogrammed (necrotic) cell death [2]
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Whilst we found that ex vivo vehicle treated cells produced high levels of cytokines, including IL-5, IL-13, IL-9 ( Supplementary Figures 4BD ), and modest amounts of IL-10 and IL-6 ( Supplementary Figures 4E, F ), melatonin treatment greatly reduced the concentration of all cytokines analyzed ( Supplementary Figures 4B F )
Synthesis, structural characterisation and antiproliferative activity of a new fluorescent 4-amino-1,8-naphthalimide Trgers base-Ru(II)-curcumin organometallic conjugate
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