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New, worsening, painful or asymmetric swelling particularly in one leg, or accompanied by breathlessness warrants prompt medical evaluation rather than a therapeutic experiment, because the causes that matter most are the ones that need to be excluded first

Epithelioids support genetic manipulation and enable the study of mutant cell competition and selection in three-dimensional epithelia, and show how anti-cancer treatments modulate competition between transformed and wild-type cells

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We're still getting used to the same day model, and now the severe restrictions of HR1 will set us back, creating backlogs as we have to screen clients further than ever before