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This action on bone metabolism caught the attention of several researchers in the area and has become a hot topic in recent years

The authors noted that human research remains limited to small pilot studies, and that no major adverse effects have been reported in published animal or early human work

doi: 10.3389/fimmu.2018.01546 272 Serna-CockLVallejo-CastilloV

One proposed mechanism is the activation of matrix metalloproteinase-9 by homocysteine, which leads to disruption of the blood-retinal barrier and increased vascular permeability in the retina [61]