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However, using a highly sensitive MethyLight method (Eads et al., 2000), the age-dependent increase in the methylation of NeuroD1 and NeuroD2 promoters was detected in the cortex (Siegmund et al., 2007)

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It is designed to selectively disrupt the FOXO4-p53 interaction in senescent cells, enabling their targeted clearance while sparing healthy cells in preclinical models

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[PubMed: 25925636] 45

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