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Two structural modifications (C18 fatty acid chain enabling albumin binding, and a substitution at position 8 conferring DPP-4 resistance) extend its half-life to approximately 1 week, enabling once-weekly subcutaneous dosing

Recent trials have shown: Up to 20% body weight reduction with weekly GLP-1 agonists (Wilding et al., NEJM) Improvements in HbA1c, fasting glucose, and cardiovascular outcomes (Marso et al., NEJM) This drug class is now widely used for: Obesity (with or without diabetes) Type 2 diabetes PCOS-related insulin resistance Metabolic syndrome Common Side Effects and Patient Concerns Despite their benefits, GLP-1 agonists are not without risks or drawbacks

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