Overall, comparison of reported K p,brain, AUC u,brain /AUC u,plasma and K p,uu,brain values for released parent drug after prodrug dosing and drug itself (Table II) revealed significant improvement of brain delivery extent after administration of the following prodruds/derivatives: L-lysine-methotrexate conjugate in mice (117), lysine derivative of ketoprofen in rats (112), phenylalanine derivatives of ketoprofen in mice (79), venlafaxine-thiamine disulfide-glucose prodrug in mice (144), glucose prodrug of ibuprofen in mice (145), ascorbic acid derivatives of ibuprofen in mice (145, 147)
Suraj Malhan, DO, headache and facial pain neurologist at RWJBarnabas Health, Monmouth Medical Center
The Calgary lifters half-inch waist change over a 13 lb gain is the textbook version of that pattern
One possibility is that the GSH:GSSG ratio is already extremely high in some compartments, as discussed above, and so cannot be increased further in response to decreases in glutathione concentration
