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The combination of Methylated CpG island amplification and representative difference analysis (DDA) has enabled the discovery of nine candidate genes, namely RASSF2, SPOCK2, RUNX3, GSTZ1, CYP2A, GBGT1, NDUFS1, ADAM22, and TRIM36, that exhibit distinctive methylation patterns associated with the malignant transformation of ovarian endometriosis (60)

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These findings were accompanied by a reduction in hippocampal neurodegeneration and inflammation, and in fact, an increase in hippocampal neuroplasticity