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Intrapancreatic fat deposition has been proposed to represent a key mediator of diseases of both the endocrine (i.e., type 2 diabetes) and exocrine pancreas (including PDAC and acute pancreatitis) 50

Body composition changes (muscle gain, fat loss) typically become noticeable around 8-12 weeks

The shorter half-life also means that IGF-1 DES needs more frequent use to keep steady-state levels, which can be advantageous or disadvantageous depending on the research protocol

Moreover, senescence cells secrete many bioactive molecules collectively termed the senescence-associated secretory phenotype (SASP), which can induce chronic inflammation, alter tissue architecture, and promote tumorigenesis through paracrine signaling