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It benefits individuals dealing with inflammatory skin conditions, such as acne
Targeting DUBs: A Novel Strategy for Cancer Therapy DUBs can be divided into six families based on their different structures: ubiquitin C-terminal hydrolases (UCHs), ubiquitin-specific proteases (USPs), ovarian-tumor proteases (OTUs), JAMM/MPN domainassociated metallopeptidases (JAMMs), MachadoJoseph disease protein domain proteases (MJD), and monocyte chemotactic protein-induced protein (MCPIP) (Mevissen and Komander, 2017)
Its mechanism relies on spatiotemporal coordination among epidermal cells, immune cells, and fibroblasts through extracellular matrix (ECM) remodeling and signaling factor cascades, involving multi-dimensional molecular interaction networks such as gene expression regulation, metabolic reprogramming, and microenvironmental homeostasis
