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Cortisol or corticosterone at concentrations compatible with arousal (but not the ones found in models of chronic unpredictable mild stress) potentiate melatonin synthesis, while concentrations compatible with immune suppression blocks it

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These include uterine overdistension, ischemia, infection, cervical disease, endocrine disorders [237], decidual hemorrhage, and maternal-fetal activation of the hypothalamic-pituitary axis, amongst others [239]

Oxidative stress, excessive inflammation, and dysregulated energy metabolism significantly contributed to liver diseases