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Research has demonstrated that B12 supplementation in deficient individuals can significantly reduce fatigue and improve physical performance

Two other studies involving 206 exposed pregnancies and 267 comparator pregnancies showed no evidence of an association with spontaneous abortion (OR 0.95

Among the 77 infants tested at 6 weeks of age, the median blood vitamin B 12 level was 199 pmol/L (270 ng/L) in the supplemented group and 139 pmol/L (188 ng/L) in the placebo group.[23] Sixty-eight pregnant women in Bangladesh received 250 mcg oral vitamin B 12 capsules or placebo once daily beginning during their first trimester of pregnancy and continuing until 3 months postpartum