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podra surgir tolerancia (aunque algunos sugieren que no provoca tolerancia fcilmente, esto no es consenso)

The 2024 Vanderbilt finding that a diastolic BP increase greater than 17 mmHg during late phase 2 of the Valsalva maneuver identifies patients with high sympathetic nerve activity is a simpler, office-based alternative to plasma catecholamine testing

13,14,19 The initial exclusions related to mental health conditions may have resulted in limited comfort in using these agents in patients with psychiatric disorders