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As noted in several studies, ketamine "drug-seeking behavior has appeared as a clinical issue, with some patients shopping infusion clinics to obtain repeated injections for mood elevation." Last year, the American Psychiatric Association issued a consensus statement on ketamine for mood disorders: "Considering the known potential for abuse of ketamine and recent reports of abuse of prescribed ketamine for the treatment of depression, clinicians should be vigilant about assessing the potential for patients to develop ketamine use disorder." The FDA has added a boxed warning to the label that which states that esketamine may cause suicidal thoughts and dissociation, and a sense of detachment from one's memory and identity

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[DOI] [PMC free article] [PubMed] [Google Scholar] 129.Lash L.H