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Unraveling the hydroxypropionaldehyde (HPA) system: an active antimicrobial agent against human pathogens

It contains sulfhydryl groups and has important antioxidant and detoxification functions

When this system becomes overwhelmed, cells, proteins, and DNA can suffer damage that accumulates over time

This sulfonamide ( 41 ) demonstrates a high metabolic stability and alters dendritic spine morphology and increases spine density in primary cultures of hippocampal neurons ( Figure 10 In addition to the sulfonamides, e.g., 40 and 41 , the spiro-oxindole dihydroquinazolinone derivative 42 was identified in the screening campaign and subsequently a large series of related analogues were made, e.g., by applying rapid MW-assisted reactions and thereafter examined as IRAP inhibitors in bioassays (Figure 10)